MovDisordV3, Main, Exploration, bibRecord, 000663

Animal models of Huntington's disease for translation to the clinic: best practices.

Identifieur interne : 000663 ( Main/Exploration ); précédent : 000662; suivant : 000664

Animal models of Huntington's disease for translation to the clinic: best practices.

Auteurs : Liliana Menalled [États-Unis] ; Daniela Brunner

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.

RBID : pubmed:25216369

English descriptors

KwdEn :
- Animals, Cognition Disorders (etiology), Disease Models, Animal, Humans, Huntington Disease (complications), Huntington Disease (therapy), Mice, Translational Medical Research (methods).
MESH :
- complications : Huntington Disease.
- etiology : Cognition Disorders.
- methods : Translational Medical Research.
- therapy : Huntington Disease.
- Animals, Disease Models, Animal, Humans, Mice.

Abstract

Mouse models of Huntington's disease (HD) recapitulate many aspects of the human disease. These genetically modified mice are powerful tools that are used not only to examine the pathogenesis of the disease, but also to assess the efficacy of potential new treatments. Disappointingly, in the past few years we have seen the success of potential therapies in animal studies, subsequently followed by failure in clinical trials. We discuss here a number of factors that influence the translatability of findings from the preclinical to the clinical realm. In particular, we discuss issues related to sample size, reporting of information regarding experimental protocols and mouse models, assignment to experimental groups, incorporation of cognitive measures for early phases of the disease, environmental enrichment, surrogate measures for survival, and the use of more than one HD mouse model. Although it is reasonable to question the appropriateness of the animal models used, we argue that it is more parsimonious to assume that improvements in experimental design and publication of negative results will lead to improved translatability to the clinic and insights about HD pathophysiology.

DOI: 10.1002/mds.26006
PubMed: 25216369

Affiliations:

Le document en format XML

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<author><name sortKey="Menalled, Liliana" sort="Menalled, Liliana" uniqKey="Menalled L" first="Liliana" last="Menalled">Liliana Menalled</name>
<affiliation wicri:level="2"><nlm:affiliation>Psychogenics Inc., Tarrytown, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Psychogenics Inc., Tarrytown, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
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<term>Huntington Disease (complications)</term>
<term>Huntington Disease (therapy)</term>
<term>Mice</term>
<term>Translational Medical Research (methods)</term>
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<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Huntington Disease</term>
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<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Translational Medical Research</term>
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<front><div type="abstract" xml:lang="en">Mouse models of Huntington's disease (HD) recapitulate many aspects of the human disease. These genetically modified mice are powerful tools that are used not only to examine the pathogenesis of the disease, but also to assess the efficacy of potential new treatments. Disappointingly, in the past few years we have seen the success of potential therapies in animal studies, subsequently followed by failure in clinical trials. We discuss here a number of factors that influence the translatability of findings from the preclinical to the clinical realm. In particular, we discuss issues related to sample size, reporting of information regarding experimental protocols and mouse models, assignment to experimental groups, incorporation of cognitive measures for early phases of the disease, environmental enrichment, surrogate measures for survival, and the use of more than one HD mouse model. Although it is reasonable to question the appropriateness of the animal models used, we argue that it is more parsimonious to assume that improvements in experimental design and publication of negative results will lead to improved translatability to the clinic and insights about HD pathophysiology.</div>
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<country name="États-Unis"><region name="État de New York"><name sortKey="Menalled, Liliana" sort="Menalled, Liliana" uniqKey="Menalled L" first="Liliana" last="Menalled">Liliana Menalled</name>
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Movement Disorders (revue)

Animal models of Huntington's disease for translation to the clinic: best practices.

Animal models of Huntington's disease for translation to the clinic: best practices.

Source :

English descriptors

Abstract

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Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Movement Disorders (revue)
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